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Have a very digenetic life cycle, involving a motile, extracellular promastigote phase that parasitizes the alimentary tract of the sandfly vector and an immotile amastigote stage that survives and replicates from the phagolysosomes of mononuclear phagocytes [two,3]. Aside from humans, Principal hosts of Leishmania, et al CDK12 inhibition reverses